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青年创新奖名单

孔宏智

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青年创新奖获奖者孔宏智

      孔宏智,生于1973年10月。博士,中国科学院植物研究所研究员。从事花的发育与进化、基因、基因家族和调控网络的进化及植物系统学和分子生物地理学研究。

      他主要从事植物系统学和植物进化发育生物学研究。主要成绩包括:1)完成了金粟兰属植物的世界性分类修订,澄清了金粟兰科各属、种的界限和关系;2)建立了SKP1和MADS-box等基因家族进化的基本框架,鉴定出几次与植物大类群起源有关的基因重复事件;3)揭示了花器官身份决定程序在被子植物起源前后的异同,提出了一个可验证的、与花起源分子机制有关的假说;4)揭示了MADS-box和F-box类基因功能分化的模式,发现非外显子序列的外显子化和外显子序列的假外显子化是重复基因结构和功能分化的重要原因;5)揭示了基因外显子一内含子结构分化的普遍性、主要机制及其相对贡献,总结和探讨了导致新基因和新基因功能产生的原因和机制;6)揭示了拟南芥中AP1和CAL基因表达分化的机制和模式,鉴定出一系列重要的转录因子结合位点,发现重复基因的表达分化是个高度动态的过程;7)把毛茛科一些植物发展成了模式,启动了“花和花瓣形态和结构多样化的分子机制”和”新性状起源的分子机制和叠加效应”等方面的探索性研究;8)揭示了毛茛科中花瓣多次丢失与APETALA3-3 (AP3-3)基因“不表达”之间的相关性,发现了导致该基因“不表达”及花瓣丢失的多种机制;9)揭示了花器官身份决定程序的可塑性和花器官在螺旋状排列时数目不固定的原因,澄清了长期以来颇有争议的A功能基因和花器官瓣化的分子机制问题;10)建立了世界上唯一一个“减数分裂数据库”(即MeioBase),促进了相关领域的研究。

  

KONG Hongzhi

Dr. KONG Hongzhi was born in October 1973. He is a Professor of lnstitute of Botany, Chinese Academy of Sciences. His major research interests include the evolutionary developmental biology ( Evo-Devo), evolutionary regulatory genomics, systematics, molecular evolution and molecular biogeography.

Dr. Kong mainly interested in plant systematics and evolutionary developmental biology (Evo-Devo). Main achievements include: 1) finished a world-wide taxonomic revision of the genus Chloranthus and clarified the boundaries and relationships between the genera and species of the family Chloranthaceae; 2) established the evolutionary framework of the SKP1 and MADS-box gene families and identified the gene duplication events related to the origins of major plant groups; 3) uncovered the commonness and peculiarities of the floral organ identity determination program before and after the origin of angiosperms and proposed a testable hypothesis for the molecular basis of the origin offlower; 4) clarified the general patterns of functional divergence of MADS-box and F-box genes and identified the cases in which divergence in exon-intron structure has played a key role in duplicate gene evolution; 5) uncovered the prevalence, mechanisms and contribution of structural divergence in duplicate gene evolution and summarized and discussed the underlying mechanisms of new gene and new function origination; 6) revealed the mechanisms underlying the divergence of the Arabidopsis AP1 and CAL genes in expression pattern, identified a few functionally important transcription factor-binding sites, and indicated that divergence of duplicate genes in expression pattern is a highly dynamic and asymmetric process; 7) developed a few species of the family Ranunculaceae into models and initiated the cutting-edge studies on the molecular bases of flower and petal evolution and the mechanisms underlying new character origination; 8) uncovered the correlation between and the underlying mechanisms of the non-expression of AP3- 3 orthologs and the parallel petallosses within the family Ranunculaceae; 9) revealed the flexibility of the floral organ identity determination program and the reason why spiral flowers usually generate variable number of floral organs and clarified the long-standing issues regarding A-function gene and petaloid floral organs; and 10) built up the first website for meiosis, MeioBase, and facilitated the studies in relevant fields.


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